Pharmacological Potential of Benzamide Analogues and their Uses in Medicinal Chemistry
نویسنده
چکیده
Benzamide derivatives possess different kinds of pharmacological activities like antimicrobial, analgesic, antiinflammatory, anticancer, cardiovascular, and other biological activities. Due to these biologically significances, scientists have interesting to develop various new benzamide derivatives. There is still need to improve the already used benzamide derivatives and search for the new and more effective benzamide derivatives. This review exhibited various pharmacophoric activities of benzamides analogues which are biologically importance. *Corresponding author: Mohammad Asif, Department of Pharmacy, GRD, PGIMT, Dehradun, Uttarakhand, India, Tel: +91 9897088910; E-mail: [email protected] Received October 31, 2016; Accepted November 18, 2016; Published November 28, 2016 Citation: Asif M (2016) Pharmacological Potential of Benzamide Analogues and their Uses in Medicinal Chemistry. Mod Chem appl 4: 194. doi: 10.4172/23296798.1000194 Copyright: © 2016 Asif M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
منابع مشابه
Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.
Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have...
متن کاملThiadiazole Analogs as Potential Pharmacological Agents: a Brief Review
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple thiadiazole nucleus possesses numerous biological properties like antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its su...
متن کاملMedicinal Uses and Pharmacological Actions of Five Commonly Used Indian Medicinal Plants: A Mini-Review
Man depends heavily on various plant species for his survival. Indian traditional system of medicine is based on empirical knowledge of the observations and the experience over millennia and more than 5000 plants are used by different ethnic communities in India. During the last few decades there has been an increasing interest in the study of medicinal plants and their traditional use in diffe...
متن کاملA Review on Chenopodium botrys L.: traditional uses, chemical composition and biological activities
Chenopodium botrys L. is native to Europe and Asia and adventive in much of North America. The plant has been used traditionally for medicinal purposes; generally, these therapeutic uses and health benefits of C. botrys are largely based on folklore rather than on scientific substantiation, making it a good candidate to gather documentations, including the phytochemical content, in vitro experi...
متن کاملSynthesis and Antimycobacterial Activity of some Triazole Derivatives–New Route to Functionalized Triazolopyridazines
A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...
متن کامل